Rnasek Gene Summary [Mouse]
Predicted to enable RNA endonuclease activity. Predicted to be involved in endosomal lumen acidification; proton transmembrane transport; and receptor-mediated endocytosis of virus by host cell. Predicted to be located in membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Is expressed in cranial ganglion; dorsal root ganglion; neural retina; and pancreas epithelium. Orthologous to human RNASEK (ribonuclease K). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Rnasek |
| Official Name | ribonuclease, RNase K [Source:MGI Symbol;Acc:MGI:106369] |
| Ensembl ID | ENSMUSG00000093989 |
| Bio databases IDs | |
| Aliases | ribonuclease, RNase K |
| Synonyms | 2310033H11Rik, D11Bwg0434e, RGD1305687, ribonuclease K, ribonuclease, RNase K |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnasek often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- endoribonuclease
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnasek gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell via receptor-mediated endocytosis
- intracellular pH reduction
- endosomal lumen acidification
- lysosomal lumen acidification
- vacuolar acidification
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- vacuolar proton-transporting V-type ATPase, V0 domain
- proton-transporting V-type ATPase complex
- membrane
- Golgi membrane
- endosome membrane
- plasma membrane
- lysosomal membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- endoribonuclease activity