Grm4 Gene Summary [Mouse]
Predicted to enable adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; calcium-dependent protein binding activity; and calmodulin binding activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within chemical synaptic transmission and learning. Located in neuron projection. Is active in cerebellar granule cell to Purkinje cell synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone membrane. Is expressed in central nervous system; dorsal root ganglion; foot; sensory organ; and skeleton. Orthologous to human GRM4 (glutamate metabotropic receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grm4 |
| Official Name | glutamate receptor, metabotropic 4 [Source:MGI Symbol;Acc:MGI:1351341] |
| Ensembl ID | ENSMUSG00000063239 |
| Bio databases IDs | |
| Aliases | glutamate receptor, metabotropic 4 |
| Synonyms | glutamate metabotropic receptor 4, glutamate receptor, metabotropic 4, GPRC1D, Metabotropic glutamate receptor 4, mGlu4, MGLUR4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- calcium-dependent protein binding
- Periplasmic binding protein
- extracellular domain
- Receptor family ligand binding region
- intracellular loop
- calmodulin binding
- G beta gamma protein binding domain
- calmodulin binding domain
- 7 transmembrane sweet-taste receptor of 3 GCPR
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- glutamate receptor
- Type 1 periplasmic binding fold superfamily
- Nine Cysteines Domain of family 3 GPCR
- group III metabotropic glutamate receptor
Pathways
Biological processes and signaling networks where the Grm4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- G-Protein Coupled Receptor Signaling
- Glutamate Receptor Signaling
- Gαi Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Phagosome Formation
- Synaptic Long Term Depression
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- Huntington disease
- sarcoidosis
- psoriasis
- cancer
- schizophrenia
- neuropathic pain
- osteosarcoma
- osteosarcomagenesis
- experimental autoimmune encephalomyelitis
regulated by
- kainic acid
- L-glutamic acid
- lipopolysaccharide
- dopamine
- L(+)-2-Amino-4-phosphonobutyric acid
- CpG oligonucleotide
- (-)-N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carbox amide
- (±)-N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carbox amide
- levodopa
- fasoracetam
role in cell
- cell viability
- expression in
- apoptosis
- proliferation
- differentiation
- morphogenesis
- synaptic transmission
- paired-pulse facilitation
- transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- neurites
- synapse
- cytoplasmic vesicles
- perikaryon
- axon terminals
- excitatory synapses
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
- synaptic transmission
- positive regulation of MAPK cascade
- G-protein coupled glutamate receptor signaling pathway
- regulation of neuron apoptotic process
- regulation of synaptic transmission, glutamatergic
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- glutamate receptor activity
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity