Ccl25 Gene Summary [Mouse]
Enables chemokine activity. Acts upstream of or within chemotaxis; leukocyte migration; and lymphoid lineage cell migration. Predicted to be active in extracellular space. Is expressed in 3rd branchial pouch; central nervous system; hemolymphoid system; retina; and thymus/parathyroid primordium. Orthologous to human CCL25 (C-C motif chemokine ligand 25). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ccl25 |
| Official Name | chemokine (C-C motif) ligand 25 [Source:MGI Symbol;Acc:MGI:1099448] |
| Ensembl ID | ENSMUSG00000023235 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) ligand 25 |
| Synonyms | A130072A22RIK, C-C motif chemokine ligand 25, CKb15, Ck beta-15, Ck β-15, SCYA25, TECK, TECKvar |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccl25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- chemokine receptor binding
- hormone
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Ccl25 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- rheumatoid arthritis
- migraines
- pervasive developmental disorder
- systemic lupus erythematosus
role in cell
- production in
- activation in
- apoptosis
- binding in
- proliferation
- migration
- accumulation
- chemotaxis
- adhesion
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccl25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- immune response
- G-protein coupled receptor signaling pathway
- positive regulation of cell-matrix adhesion
- eosinophil chemotaxis
- chemokine-mediated signaling pathway
- cell surface receptor signaling pathway
- positive regulation of GTPase activity
- cell chemotaxis
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- CCR chemokine receptor binding
- CCR10 chemokine receptor binding
- chemokine activity
- chemokine receptor binding
- hormone activity