Ccr9 Gene Summary [Mouse]
Enables C-C chemokine receptor activity. Acts upstream of or within CD8-positive, gamma-delta intraepithelial T cell differentiation and chemotaxis. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; immune system; intestine; and retina. Orthologous to human CCR9 (C-C motif chemokine receptor 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr9 |
| Official Name | chemokine (C-C motif) receptor 9 [Source:MGI Symbol;Acc:MGI:1341902] |
| Ensembl ID | ENSMUSG00000029530 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 9 |
| Synonyms | A130091K22RIK, CC-CKR-9, C-C motif chemokine receptor 9, CDw199, Cmkbr10, GPR28, GPR-9-6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ccr9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- Crohn disease
- COVID-19
- T acute lymphoblastic leukemia
- atherosclerosis
- colorectal cancer
- critical COVID-19
- insulin-dependent diabetes mellitus
role in cell
- expression in
- chemotaxis
- migration
- response
- differentiation
- number
- abnormal morphology
- quantity
- development
- cellular subpopulation ratio
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccr9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- cellular defense response
- immune response
- CD8-positive, gamma-delta intraepithelial T cell differentiation
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- calcium-mediated signaling
- elevation of cytosolic calcium ion concentration
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- C-C chemokine receptor activity
- chemokine receptor activity