Ccl5 Gene Summary [Mouse]
Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl5 |
| Official Name | chemokine (C-C motif) ligand 5 [Source:MGI Symbol;Acc:MGI:98262] |
| Ensembl ID | ENSMUSG00000035042 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) ligand 5 |
| Synonyms | C-C motif chemokine ligand 5, D17S136E, eoCP, MuRantes, RANTES, RNTES, SCYA5, Similar to merantes, SISd, SIS-delta, SIS-δ, TCP228 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemoattractant
- chemokine receptor binding
- heparin binding domain
- N-loop domain
- protein binding
- cytokine
- phospholipase activator
- identical protein binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- glycosaminoglycan attachment site
- protein homodimerization
- chemokine receptor antagonist
- receptor signaling protein tyrosine kinase activator
- heparin binding
Pathways
Biological processes and signaling networks where the Ccl5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- CCR5 Signaling in Macrophages
- Chemokine Signaling
- Communication between Innate and Adaptive Immune Cells
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-17A Signaling in Gastric Cells
- Neuroinflammation Signaling Pathway
- Pathogenesis of Multiple Sclerosis
- Renin-Angiotensin Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of IL-17A in Arthritis
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- lung cancer
- thoracic cancer
- cancer
- metastasis
- colorectal cancer
- pancreatic epithelial cancer
- ductal pancreatic cancer
- plaque psoriasis
role in cell
- expression in
- production in
- chemotaxis
- apoptosis
- activation in
- proliferation
- migration
- cell death
- quantity
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- perinuclear Golgi regions
- cell surface
- intracellular space
- cellular membrane
- vesicles
- Golgi Apparatus
- granules
- cytotoxic granule
- secretory granules
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of homotypic cell-cell adhesion
- positive chemotaxis
- positive regulation of calcium ion transport
- positive regulation of tyrosine phosphorylation of STAT protein
- exocytosis
- response to toxin
- positive regulation of GTPase activity
- cell chemotaxis
- regulation of chronic inflammatory response
- regulation of insulin secretion
- inflammatory response
- epithelial cell proliferation
- macrophage chemotaxis
- eosinophil chemotaxis
- positive regulation of activation of Janus kinase activity
- negative regulation of macrophage apoptotic process
- positive regulation of epithelial cell proliferation
- G-protein coupled receptor signaling pathway
- positive regulation of monocyte chemotaxis
- cell-cell signaling
- positive regulation of T cell proliferation
- positive regulation of JAK-STAT cascade
- positive regulation of T cell migration
- negative regulation of T cell apoptotic process
- dendritic cell chemotaxis
- positive regulation of T cell chemotaxis
- positive regulation of T cell apoptotic process
- activation of phospholipase D activity
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- positive regulation of translational initiation
- negative regulation by host of viral transcription
- neutrophil activation
- positive regulation of cell adhesion
- response to virus
- negative regulation of G-protein coupled receptor protein signaling pathway
- leukocyte cell-cell adhesion
- positive regulation of G-protein coupled receptor protein signaling pathway
- positive regulation of smooth muscle cell proliferation
- chemotaxis
- negative regulation of chemokine-mediated signaling pathway
- positive regulation of macrophage chemotaxis
- calcium ion transport
- cellular response to tumor necrosis factor
- positive regulation of smooth muscle cell migration
- positive regulation of viral genome replication
- negative regulation of viral genome replication
- positive regulation of cell-cell adhesion mediated by integrin
- positive regulation of phosphorylation
- cellular response to fibroblast growth factor stimulus
- cellular calcium ion homeostasis
- positive regulation of cellular biosynthetic process
- positive regulation of innate immune response
- positive regulation of natural killer cell chemotaxis
- monocyte chemotaxis
- chemokine-mediated signaling pathway
- cellular response to interleukin-1
- cellular response to interferon-gamma
- regulation of T cell activation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- chemokine receptor antagonist activity
- identical protein binding
- protein homodimerization activity
- chemoattractant activity
- protein kinase activity
- chemokine activity
- chemokine receptor binding
- CCR1 chemokine receptor binding
- phosphatidylinositol phospholipase C activity
- protein binding
- CCR chemokine receptor binding
- CCR4 chemokine receptor binding
- receptor signaling protein tyrosine kinase activator activity
- phospholipase activator activity
- CCR5 chemokine receptor binding