Maz Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system; limb; nervous system; and retina. Orthologous to human MAZ (MYC associated zinc finger protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Maz |
| Official Name | MYC-associated zinc finger protein (purine-binding transcription factor) [Source:MGI Symbol;Acc:MGI:1338823] |
| Ensembl ID | ENSMUSG00000030678 |
| Bio databases IDs | |
| Aliases | MYC-associated zinc finger protein (purine-binding transcription factor) |
| Synonyms | MAZI, MYC associated zinc finger protein, MYC-associated zinc finger protein (purine-binding transcription factor), MYC ASSOCIATED ZNF, PUR1, SAF-1, ZF87, Zif87, ZNF801 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Maz often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- chromatin binding
- protein binding
- zinc finger domain
- MAP kinase site
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- tumorigenesis
- colon cancer
- organismal death
- glioblastoma
- glioblastoma cancer
- osteoarthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- expression in
- growth
- activation in
- phosphorylation in
- cell death
- migration
- proliferation
- formation
- formation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Maz gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- positive regulation of cell proliferation
- termination of RNA polymerase II transcription
- negative regulation of apoptotic signaling pathway
- positive regulation of protein kinase B signaling cascade
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity