Guca2a Gene Summary [Mouse]
Predicted to enable guanylate cyclase activator activity. Predicted to be located in extracellular region. Is expressed in several structures, including Meckel's cartilage; axial skeleton; esophagus; ganglia; and lower urinary tract. Orthologous to human GUCA2A (guanylate cyclase activator 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Guca2a |
| Official Name | guanylate cyclase activator 2a (guanylin) [Source:MGI Symbol;Acc:MGI:102738] |
| Ensembl ID | ENSMUSG00000023247 |
| Bio databases IDs | |
| Aliases | guanylate cyclase activator 2a (guanylin) |
| Synonyms | GCAP-I, GUANYL, guanylate cyclase activator 2A, guanylate cyclase activator 2a (guanylin), Guanylin, GUCA2, STARA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Guca2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanylate cyclase activator
- protein binding
- Guanylin precursor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- neoplasia
- colorectal cancer
- colorectal adenoma
- colorectal adenoma formation
role in cell
- apoptosis
- migration
- proliferation
- expression in
- quantity
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Guca2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanylate cyclase activator activity
- hormone activity