Grp Gene Summary [Mouse]
This gene encodes a neuropeptide hormone that affects various biological processes such as neuroendocrine regulation, gastrointestinal secretion, nociception, cell proliferation and inflammation. The encoded protein undergoes proteolytic processing to generate multiple mature peptides with biological activity. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Grp |
| Official Name | gastrin releasing peptide [Source:MGI Symbol;Acc:MGI:95833] |
| Ensembl ID | ENSMUSG00000024517 |
| Bio databases IDs | |
| Aliases | gastrin releasing peptide |
| Synonyms | BLP, BN, Gastrin-releasing Peptide, GRP-10, preproGRP, proGRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bombesin-like peptide
- protein binding
- neuropeptide hormone
- growth factor
Pathways
Biological processes and signaling networks where the Grp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- schizophrenia
- hyperplasia
- hypothermia
- hyperglycemia
- tumorigenesis
- rheumatoid arthritis
- hyperinsulinism
- atopic dermatitis
role in cell
- expression in
- activation in
- proliferation
- cell cycle progression
- growth
- degranulation
- synthesis in
- morphology
- formation
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Cytoplasm
- neurites
- secretory granules
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- response to external biotic stimulus
- neuropeptide signaling pathway
- positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of behavioral fear response
- ossification
- signal transduction
- positive regulation of peptide hormone secretion
- regulation of gene expression
- mast cell degranulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule lumen
- extracellular region
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide hormone activity
- receptor binding