Slc34a2 Gene Summary [Mouse]
Enables sodium:phosphate symporter activity. Acts upstream of or within in utero embryonic development and phosphate ion transport. Located in apical plasma membrane and brush border. Is expressed in several structures, including egg cylinder; genitourinary system; small intestine; and tooth. Human ortholog(s) of this gene implicated in pulmonary alveolar microlithiasis. Orthologous to human SLC34A2 (solute carrier family 34 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc34a2 |
| Official Name | solute carrier family 34 (sodium phosphate), member 2 [Source:MGI Symbol;Acc:MGI:1342284] |
| Ensembl ID | ENSMUSG00000029188 |
| Bio databases IDs | |
| Aliases | solute carrier family 34 (sodium phosphate), member 2 |
| Synonyms | D5Ertd227e, NaPi-2b, NAPI-3B, NAPI-IIb, Npt2b, NPTIIb, PULAM, solute carrier family 34 member 2, solute carrier family 34 (sodium phosphate), member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc34a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphate:Na+ Symporter (PNaS) Family
- metal ion binding
- protein domain specific binding
- protein binding
- sodium:phosphate symporter
- phosphate binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial thyroid cancer
- primary peritoneal serous cancer
- familial colorectal cancer
- high grade recurrent serous ovarian cancer
- high-grade serous fallopian tube cancer
- primary ovarian cancer
- proximal tubular toxicity
- lung adenocarcinoma formation
- pulmonary alveolar microlithiasis
- hypercalciuria
regulates
- phosphate
- vitamin D
- creatinine
role in cell
- proliferation
- cell cycle progression
- formation
- migration
- substrate adhesion
- invasion by
- formation in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- apical membrane
- brush border
- microvilli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc34a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein metabolic process
- response to estrogen stimulus
- phosphate ion transport
- in utero embryonic development
- sodium-dependent phosphate transport
- sodium ion transmembrane transport
- cellular phosphate ion homeostasis
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- brush border
- membrane
- vesicle
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium:phosphate symporter activity
- phosphate ion binding
- sodium ion binding