Gcm1 Gene Summary [Mouse]
Enables DNA binding activity and zinc ion binding activity. Acts upstream of or within several processes, including astrocyte fate commitment; embryonic placenta development; and positive regulation of syncytium formation by plasma membrane fusion. Located in nucleus. Is expressed in several structures, including extraembryonic component; metanephros; pancreas; placenta; and thymus. Orthologous to human GCM1 (glial cells missing transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gcm1 |
| Official Name | glial cells missing homolog 1 [Source:MGI Symbol;Acc:MGI:108045] |
| Ensembl ID | ENSMUSG00000023333 |
| Bio databases IDs | |
| Aliases | glial cells missing homolog 1 |
| Synonyms | Gcm1-rs1, GCMA, Gcm-rs2, glial cells missing homolog 1, glial cells missing transcription factor 1, glide, hGCMa, LOC105375094 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gcm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- transcription factor binding
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- GCM motif protein
- zinc ion binding
- double-stranded DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diastematomyelia
- early-onset preeclampsia
- spina bifida
role in cell
- expression in
- activation in
- differentiation
- binding in
- cell-cell fusion
- fusion
- desumoylation in
- syncytialization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gcm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of syncytium formation by plasma membrane fusion
- branching involved in labyrinthine layer morphogenesis
- regulation of cell differentiation involved in embryonic placenta development
- syncytium formation by plasma membrane fusion
- transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- anatomical structure morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- astrocyte fate commitment
- regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- gliogenesis
- cell differentiation involved in embryonic placenta development
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity