Fzd5 Gene Summary [Mouse]
Enables Wnt-protein binding activity. Involved in camera-type eye development; canonical Wnt signaling pathway; and positive regulation of cytokine production. Acts upstream of or within several processes, including columnar/cuboidal epithelial cell maturation; embryonic organ development; and positive regulation of macromolecule metabolic process. Located in several cellular components, including Golgi apparatus; bicellular tight junction; and perinuclear region of cytoplasm. Colocalizes with early endosome. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; eye; and genitourinary system. Orthologous to human FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fzd5 |
| Official Name | frizzled class receptor 5 [Source:MGI Symbol;Acc:MGI:108571] |
| Ensembl ID | ENSMUSG00000045005 |
| Bio databases IDs | |
| Aliases | frizzled class receptor 5 |
| Synonyms | 5330434N09Rik, AI427138, C2orf31, DKFZP434E2135, frizzled class receptor 5, Fz-5, HFZ5, MCOPCB11, mFz5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fzd5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- ubiquitin protein ligase binding
- Wnt-protein binding
- Frizzled/Smoothened family membrane region
- protein kinase binding
- Wnt receptor
- Fz domain
- protein binding
- beta-amyloid binding
- seven-transmembrane G protein-coupled receptor superfamily
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
- binding protein
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Fzd5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Basal Cell Carcinoma Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- CREB Signaling in Neurons
- Factors Promoting Cardiogenesis in Vertebrates
- G-Protein Coupled Receptor Signaling
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- autosomal dominant ocular coloboma
- microphthalmia/coloboma type 11
- bleeding
role in cell
- proliferation
- expression in
- phosphorylation in
- differentiation
- branching
- branching in
- dissociation
- activation
- phagocytosis
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- endocytic vesicle membrane
- cell surface
- perinuclear region
- cellular membrane
- Golgi Apparatus
- endosomal membrane
- growth cone
- neurites
- synapse
- early endosomes
- tight junctions
- axons
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fzd5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process involved in morphogenesis
- negative regulation of cell proliferation
- embryonic axis specification
- positive regulation of transcription from RNA polymerase II promoter
- angiogenesis
- positive regulation of interferon-gamma production
- canonical Wnt receptor signaling pathway
- post-embryonic camera-type eye development
- positive regulation of tumor necrosis factor production
- regulation of tight junction assembly
- cellular response to molecule of bacterial origin
- intestinal epithelial cell maturation
- anterior/posterior axis specification, embryo
- G-protein coupled receptor signaling pathway
- T cell differentiation in thymus
- neuron differentiation
- glandular epithelial cell maturation
- branching involved in labyrinthine layer morphogenesis
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development
- synapse assembly
- labyrinthine layer blood vessel development
- chorionic trophoblast cell differentiation
- embryonic camera-type eye morphogenesis
- positive regulation of T cell cytokine production
- Spemann organizer formation
- positive regulation of interleukin-1 beta production
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- dendrite
- tight junction
- perinuclear region of cytoplasm
- clathrin-coated endocytic vesicle membrane
- Golgi membrane
- synapse
- perikaryon
- plasma membrane
- axon
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- G-protein coupled receptor activity
- Wnt-activated receptor activity
- protein binding
- ubiquitin protein ligase binding
- lipid binding
- Wnt-protein binding
- beta-amyloid binding