Rhag Gene Summary [Mouse]
Enables ammonium channel activity and methylammonium transmembrane transporter activity. Involved in methylammonium transmembrane transport. Acts upstream of or within ammonium transmembrane transport; erythrocyte development; and multicellular organismal-level iron ion homeostasis. Predicted to be located in membrane. Predicted to be part of ankyrin-1 complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cerebral cortex; liver; and spleen. Human ortholog(s) of this gene implicated in Rh deficiency syndrome; hemolytic anemia; and overhydrated hereditary stomatocytosis. Orthologous to human RHAG (Rh associated glycoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rhag |
| Official Name | Rhesus blood group-associated A glycoprotein [Source:MGI Symbol;Acc:MGI:1202713] |
| Ensembl ID | ENSMUSG00000023926 |
| Bio databases IDs | |
| Aliases | Rhesus blood group-associated A glycoprotein |
| Synonyms | CD241, LOC100361616, OHS, OHST, RH2, Rh50, RH50A, Rh50GP, Rh-associated glycoprotein, Rhesus blood group-associated A glycoprotein, RHNR, SLC42A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rhag often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methylammonium transporter
- ankyrin binding
- channel/pore class transporter
- peptidase
- protein binding
- cytosolic tail domain
- ammonium transporter
- transporter
- Ammonium Transporter Family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- regulator type Rh-null hemolytic anemia
- overhydrated hereditary stomatocytosis
- Rh mod syndrome
- Rh deficiency syndrome
role in cell
- expression in
- cell death
- binding
- function
- development
- ion homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- intracellular space
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rhag gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- ammonium transmembrane transport
- carbon dioxide transport
- erythrocyte development
- methylammonium transmembrane transport
- carbon dioxide transmembrane transport
- ammonia homeostasis
- bicarbonate transport
- cellular ion homeostasis
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ammonium transmembrane transporter activity
- methylammonium transmembrane transporter activity
- protein binding
- ankyrin binding
- carbon dioxide transmembrane transporter activity
- leak channel activity