RHAG Gene Summary [Human]
The protein encoded by this gene is erythrocyte-specific and is thought to be part of a membrane channel that transports ammonium and carbon dioxide across the blood cell membrane. The encoded protein appears to interact with Rh blood group antigens and Rh30 polypeptides. Defects in this gene are a cause of regulator type Rh-null hemolytic anemia (RHN), or Rh-deficiency syndrome.[provided by RefSeq, Mar 2009]
Details
| Type | Protein Coding |
| Official Symbol | RHAG |
| Official Name | Rh associated glycoprotein [Source:HGNC Symbol;Acc:HGNC:10006] |
| Ensembl ID | ENSG00000112077 |
| Bio databases IDs | |
| Aliases | Rh associated glycoprotein, Ammonium transporter Rh type A |
| Synonyms | CD241, LOC100361616, OHS, OHST, RH2, Rh50, RH50A, Rh50GP, Rh-associated glycoprotein, Rhesus blood group-associated A glycoprotein, RHNR, SLC42A1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RHAG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methylammonium transporter
- ankyrin binding
- channel/pore class transporter
- peptidase
- protein binding
- cytosolic tail domain
- ammonium transporter
- transporter
- Ammonium Transporter Family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- regulator type Rh-null hemolytic anemia
- overhydrated hereditary stomatocytosis
- Rh mod syndrome
- Rh deficiency syndrome
role in cell
- expression in
- cell death
- binding
- function
- development
- ion homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- intracellular space
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RHAG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- ammonium transmembrane transport
- carbon dioxide transport
- erythrocyte development
- methylammonium transmembrane transport
- carbon dioxide transmembrane transport
- ammonia homeostasis
- bicarbonate transport
- cellular ion homeostasis
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ammonium transmembrane transporter activity
- methylammonium transmembrane transporter activity
- protein binding
- ankyrin binding
- carbon dioxide transmembrane transporter activity
- leak channel activity