Pgc Gene Summary [Mouse]
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in positive regulation of antibacterial peptide production and proteolysis. Predicted to be active in extracellular space. Is expressed in gut and lung. Orthologous to human PGC (progastricsin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgc |
| Official Name | progastricsin (pepsinogen C) [Source:MGI Symbol;Acc:MGI:98909] |
| Ensembl ID | ENSMUSG00000023987 |
| Bio databases IDs | |
| Aliases | progastricsin (pepsinogen C) |
| Synonyms | 2210410L06Rik, GASTRICSIN, PEPC, PG1, PGII, progastricsin, progastricsin (pepsinogen C), Upg-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gastricsin
- Xylanase inhibitor N-terminal
- A1 Propeptide
- peptidase
- aspartic endopeptidase
- Cellular and retroviral pepsin-like aspartate proteases
- Eukaryotic aspartyl protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- non-small cell lung cancer
- gastric adenocarcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- pancreatic neoplasia
- pancreatic neoplasm
- non-small cell lung carcinoma
- gastric epithelial cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of antibacterial peptide production
- proteolysis
- digestion
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- aspartic-type endopeptidase activity