Mtch1 Gene Summary [Mouse]
Predicted to enable membrane insertase activity. Predicted to be involved in positive regulation of apoptotic process and protein insertion into mitochondrial outer membrane. Located in mitochondrion. Is expressed in cerebral cortex marginal layer; choroid invagination; diencephalon roof plate; metencephalon part of 4th ventricle choroid plexus; and thyroid gland. Orthologous to human MTCH1 (mitochondrial carrier 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtch1 |
| Official Name | mitochondrial carrier 1 [Source:MGI Symbol;Acc:MGI:1929261] |
| Ensembl ID | ENSMUSG00000024012 |
| Bio databases IDs | |
| Aliases | mitochondrial carrier 1 |
| Synonyms | 2310034O17Rik, CGI-64, mitochondrial carrier 1, PIG60, PSAP, SLC25A49 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtch1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitochondrial carrier protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- lung adenocarcinoma formation
- diverticular disease
- lung adenocarcinoma
role in cell
- apoptosis
- growth
- cell death
- activity
- oxidative phosphorylation in
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtch1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into mitochondrial outer membrane
- neuronal ion channel clustering
- positive regulation of apoptotic process
- apoptotic process
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- membrane
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- membrane insertase activity
- protein binding