Ddrgk1 Gene Summary [Mouse]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; UFM1-modified protein reader activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including negative regulation of endoplasmic reticulum unfolded protein response; positive regulation of plasma cell differentiation; and positive regulation of protein localization to endoplasmic reticulum. Is active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver and biliary system; and nervous system. Orthologous to human DDRGK1 (DDRGK domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ddrgk1 |
| Official Name | DDRGK domain containing 1 [Source:MGI Symbol;Acc:MGI:1924256] |
| Ensembl ID | ENSMUSG00000068290 |
| Bio databases IDs | |
| Aliases | DDRGK domain containing 1 |
| Synonyms | 1110001I20Rik, 2600009E05Rik, C20orf116, DDRGK domain containing 1, dJ1187M17.3, RGD1309979, SEMDSH, UFBP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddrgk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- enzyme binding
- transcription factor binding
- protein binding
- DDRGK domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- thrombocytopenia
- Shohat type spondyloepimetaphyseal dysplasia
- renal cell carcinoma
- renal cell cancer
role in cell
- expression in
- proliferation
- apoptosis
- migration
- differentiation
- colony formation
- binding in
- autophagy
- autophagy in
- protein ufmylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddrgk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of plasma cell differentiation
- ribosome disassembly
- positive regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of gene expression
- regulation of protein stability
- rescue of stalled ribosome
- positive regulation of gene expression
- negative regulation of apoptotic process
- regulation of intracellular estrogen receptor signaling pathway
- protein localization in endoplasmic reticulum
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ufmylation
- response to endoplasmic reticulum stress
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of cell migration
- cartilage development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- endoplasmic reticulum
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- small conjugating protein ligase binding