Lgals3 Gene Summary [Mouse]
Predicted to enable several functions, including IgE binding activity; advanced glycation end-product receptor activity; and signaling receptor binding activity. Involved in negative regulation of T cell receptor signaling pathway; negative regulation of endocytosis; and negative regulation of lymphocyte activation. Acts upstream of or within extracellular matrix organization and skeletal system development. Located in several cellular components, including external side of plasma membrane; glial cell projection; and immunological synapse. Is active in cornified envelope. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; skeleton; and skin. Used to study steatotic liver disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgals3 |
| Official Name | lectin, galactose binding, soluble 3 [Source:MGI Symbol;Acc:MGI:96778] |
| Ensembl ID | ENSMUSG00000050335 |
| Bio databases IDs | |
| Aliases | lectin, galactose binding, soluble 3 |
| Synonyms | AGE-R3, CBP30, CBP35, GAL3, GALBP, GALECTIN-3, GALIG, GALIG ORF1, GALIG ORF2, GBP, IgE binding, L31, L-34, lectin, galactose binding, soluble 3, LEG3, LGALS2, MAC2, MTIOGALIGIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lgals3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Casein kinase i phosphorylation site
- signaling receptor activity
- chemoattractant
- protein phosphatase binding
- carbohydrate recognition domain
- protein binding activity, bridging
- receptor inhibitor
- disaccharide binding
- protein binding
- receptor binding
- phosphorylation site
- protein phosphatase inhibitor activity
- binding protein
- glycine proline rich domain
- monosaccharide binding
- laminin binding
- serine phosphorylation site
- NWGR motif
- carbohydrate binding
- GLECT
- lectin domain
- IgE binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- preeclampsia
- liver cancer
- liver neoplasia
- epithelial cancer
- abdominal cancer
- digestive system cancer
- epithelial neoplasia
- non-insulin-dependent diabetes mellitus
role in cell
- growth
- proliferation
- survival
- expression in
- production in
- degradation in
- apoptosis
- phosphorylation in
- cell rolling
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- nuclear fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cornified envelope
- blood microparticle
- Cytoplasm
- cell-matrix contacts
- cell surface
- cell borders
- intracellular space
- basal compartment
- Nucleus
- Plasma Membrane
- centrosome
- Mitochondria
- immunological synapses
- secretory granule membrane
- cytosol
- basal cytoplasm
- basolateral cytoplasm
- primary cilia
- plasma membrane extracellular face
- lateral plasma membrane
- mitochondrial inner membrane
- nucleoplasm
- glial cell projections
- extracellular matrix
- membrane rafts
- exosomes
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lgals3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- negative regulation of endocytosis
- RNA splicing
- positive chemotaxis
- mRNA processing
- positive regulation of calcium ion import
- epithelial cell differentiation
- negative regulation of T cell receptor signaling pathway
- regulation of T cell apoptotic process
- macrophage chemotaxis
- mononuclear cell migration
- monocyte chemotaxis
- innate immune response
- eosinophil chemotaxis
- negative regulation of immunological synapse formation
- positive regulation of mononuclear cell migration
- neutrophil chemotaxis
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- positive regulation of dendritic cell differentiation
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- spliceosomal complex
- extracellular region
- mitochondrial inner membrane
- plasma membrane
- immunological synapse
- nucleoplasm
- cell surface
- secretory granule membrane
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein phosphatase binding
- RNA binding
- protein binding
- chemoattractant activity
- IgE binding
- carbohydrate binding
- disaccharide binding
- laminin binding