Washc2 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and retromer complex binding activity. Predicted to be involved in protein localization to endosome and retrograde transport, endosome to Golgi. Part of WASH complex. Is expressed in several structures, including extraembryonic component; liver; and neural retina. Orthologous to human WASHC2A (WASH complex subunit 2A) and WASHC2C (WASH complex subunit 2C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Washc2 |
| Official Name | WASH complex subunit 2` [Source:MGI Symbol;Acc:MGI:106463] |
| Ensembl ID | ENSMUSG00000024104 |
| Bio databases IDs | |
| Aliases | WASH complex subunit 2` |
| Synonyms | A130095H06, C530005J20Rik, D6Wsu116e, FAM21, FAM21A, FAM21C, KIAA0592, NP61201, VPEF, Washc2, WASH complex subunit 2, WASH complex subunit 2C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Washc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WASH complex subunit CAP-Z interacting, central region
- binding protein
- phosphatidylinositol-3,4,5-triphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- phosphatidylinositol binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endosomes
- cytosol
- nucleoli
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Washc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of barbed-end actin filament capping
- protein localization in endosome
- protein transport
- endosomal transport
- regulation of substrate adhesion-dependent cell spreading
- retrograde transport, endosome to Golgi
- endocytic recycling
- regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- early endosome
- endosome
- intracellular membrane-bounded organelle
- cytosol
- WASH complex
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylinositol-4-phosphate binding
- protein binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,4-bisphosphate binding