Capzb Gene Summary [Mouse]
This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Capzb |
| Official Name | capping protein (actin filament) muscle Z-line, beta [Source:MGI Symbol;Acc:MGI:104652] |
| Ensembl ID | ENSMUSG00000028745 |
| Bio databases IDs | |
| Aliases | capping protein (actin filament) muscle Z-line, beta |
| Synonyms | 1700120C01Rik, CAPB, CAPPB, Cappb1, capping actin protein of muscle Z-line subunit beta, capping actin protein of muscle Z-line subunit β, Capping protein beta 1, Capping protein β 1, CAPZ, Capzb2, CapZbeta, CapZβ, CP, CPB1, CPB2, CPbeat2, CPbeta1, F-Actin Capping Protein beta, F-Actin Capping Protein β, F-CAPPING |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Capzb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin binding
- protein binding
- F-actin capping protein, beta subunit
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- nonfamilial Alzheimer disease
- hypothyroidism
- chronic obstructive pulmonary disease
- idiopathic scoliosis
- lung adenocarcinoma formation
- lung adenocarcinoma
- Parkinson disease
- psoriasis
- atopic dermatitis
role in cell
- quantity
- tension
- growth
- morphology
- density
- maturation
- assembly
- growth in
- organization
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical cytoskeleton
- cytoskeleton
- cellular membrane
- actin cytoskeleton
- Nucleus
- Mitochondria
- cytosol
- dendritic spines
- growth cone
- synapse
- intercalated disks
- Z line
- membrane rafts
- brush border
- perikaryon
- postsynaptic density
- exosomes
- phagosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Capzb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- barbed-end actin filament capping
- regulation of lamellipodium assembly
- cytoskeleton organization
- regulation of cell morphogenesis
- actin polymerization or depolymerization
- cell morphogenesis
- lamellipodium assembly
- negative regulation of filopodium assembly
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular vesicular exosome
- cytoskeleton
- brush border
- membrane
- actin cytoskeleton
- cytosol
- WASH complex
- F-actin capping protein complex
- sarcomere
- lamellipodium
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- cadherin binding