Vps26a Gene Summary [Mouse]
Acts upstream of or within retrograde transport, endosome to Golgi. Located in early endosome. Part of retromer complex. Is expressed in several structures, including egg cylinder; embryo ectoderm; gut; inner cell mass; and ovary. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to human VPS26A (VPS26 retromer complex component A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps26a |
| Official Name | VPS26 retromer complex component A [Source:MGI Symbol;Acc:MGI:1353654] |
| Ensembl ID | ENSMUSG00000020078 |
| Bio databases IDs | |
| Aliases | VPS26 retromer complex component A |
| Synonyms | HB58, Hbeta58, PEP8A, VPS26, VPS26 retromer complex component A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps26a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vacuolar protein sorting-associated protein 26
- protein binding
- Arrestin (or S-antigen), N-terminal domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- exencephaly
- non-insulin-dependent diabetes mellitus
- Parkinson disease
- growth failure
- bleeding
- rotator cuff injury
role in cell
- activation in
- invasion by
- degradation in
- stability
- function in
- swelling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- membrane fraction
- endosomal bud
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- cytoplasmic aggregates
- cytosol
- basolateral membrane
- basal membrane
- endosomal compartment
- endosomal membrane
- early endosomes
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps26a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macroautophagy
- retrograde transport, endosome to Golgi
- intracellular protein transport
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- early endosome
- endosome
- retromer complex
- cytosol
- retromer complex, inner shell
- vesicle
- endosome membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding