Eci1 Gene Summary [Mouse]
Enables delta(3)-delta(2)-enoyl-CoA isomerase activity. Acts upstream of or within fatty acid beta-oxidation. Located in mitochondrial inner membrane. Is expressed in cerebral cortex and testis. Orthologous to human ECI1 (enoyl-CoA delta isomerase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eci1 |
| Official Name | enoyl-Coenzyme A delta isomerase 1 [Source:MGI Symbol;Acc:MGI:94871] |
| Ensembl ID | ENSMUSG00000024132 |
| Bio databases IDs | |
| Aliases | enoyl-Coenzyme A delta isomerase 1 |
| Synonyms | DCI, Dci1, Delta3,Delta2-Enoyl-CoA Isomerase, Dodecenoyl CoA δ Isomerase, eci, enoyl-CoA delta isomerase 1, enoyl-CoA δ isomerase 1, enoyl-Coenzyme A delta isomerase 1, enoyl-Coenzyme A δ isomerase 1, MECI, Miso |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eci1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dodecenoyl-CoA D-isomerase
- carbon-carbon double bond transposing intramolecular oxidoreductase
- crotonase-like
- enzyme
- identical protein binding
- Enoyl-CoA hydratase/isomerase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- medium chain dicarboxylic acid
- fatty acid
- PPARA
- triacylglycerol
- C12:1 acylcarnitine
- lipid
- Cyp4a10 (includes others)
role in cell
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eci1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- dodecenoyl-CoA delta-isomerase activity
- intramolecular oxidoreductase activity, transposing C=C bonds