Ace2 Gene Summary [Mouse]
Enables metallocarboxypeptidase activity. Involved in angiotensin maturation; positive regulation of cardiac muscle contraction; and tryptophan transport. Located in brush border membrane and cytoplasm. Is active in extracellular region. Is expressed in several structures, including blastocyst; brain; early embryo; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including avian influenza; cerebral malaria; hypertension (multiple); respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ace2 |
| Official Name | angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 [Source:MGI Symbol;Acc:MGI:1917258] |
| Ensembl ID | ENSMUSG00000015405 |
| Bio databases IDs | |
| Aliases | angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 |
| Synonyms | 2010305L05Rik, ACEH, angiotensin converting enzyme 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ace2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Angiotensin-converting enzyme
- carboxypeptidase
- viral receptor
- ectodomain
- peptidase
- metallocarboxypeptidase
- protein binding
- Renal amino acid transporter
- identical protein binding
- metallopeptidase
- endopeptidase
- cytoplasmic domain
- zinc ion binding
- transmembrane/cytoplasmic domain
- transmembrane domain
- cytosolic tail domain
- peptidyl-dipeptidase
- peptidase GluZincin family
- peptidyl-dipeptidase A
Pathways
Biological processes and signaling networks where the Ace2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- epithelial cancer
- epithelial neoplasia
- cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- diabetes mellitus
- dilated cardiomyopathy
role in cell
- expression in
- production in
- proliferation
- apoptosis
- number
- degradation in
- binding
- activation in
- cellular infiltration by
- syncytium formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- tetraspanin-enriched microdomain
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- apical cell surfaces
- endoplasmic reticulum lumen
- apical membrane
- dendrite initial segments
- membrane rafts
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ace2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- positive regulation of cardiac muscle contraction
- membrane fusion
- maternal process involved in female pregnancy
- regulation of systemic arterial blood pressure by renin-angiotensin
- negative regulation of receptor activity
- angiotensin-mediated drinking behavior
- regulation of transmembrane transporter activity
- virion attachment, binding of host cell surface receptor
- regulation of cell proliferation
- angiotensin maturation
- viral entry into host cell via receptor-mediated endocytosis
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of smooth muscle cell proliferation
- viral infectious cycle
- tryptophan transport
- regulation of inflammatory response
- regulation of cytokine production
- positive regulation of amino acid transport
- positive regulation of reactive oxygen species metabolic process
- regulation of vasoconstriction
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
- cell surface
- endoplasmic reticulum lumen
- extracellular space
- brush border membrane
- extracellular vesicular exosome
- membrane
- membrane raft
- cilium
- endocytic vesicle membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- carboxypeptidase activity
- protein binding
- metallocarboxypeptidase activity
- peptidyl-dipeptidase activity
- endopeptidase activity
- viral receptor activity
- metallopeptidase activity