Atp6v1g2 Gene Summary [Mouse]
Enables ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Located in synaptic vesicle membrane. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including nervous system. Orthologous to human ATP6V1G2 (ATPase H+ transporting V1 subunit G2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Atp6v1g2 |
| Official Name | ATPase, H+ transporting, lysosomal V1 subunit G2 [Source:MGI Symbol;Acc:MGI:1913487] |
| Ensembl ID | ENSMUSG00000024403 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V1 subunit G2 |
| Synonyms | 1500002D01Rik, ATP6G, ATP6G2, ATPase, H+ transporting, lysosomal V1 subunit G2, ATPase H+ transporting V1 subunit G2, NG38, VAG2, V-ATPase G2, V-ATPase V1-G2, VMA10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v1g2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vacuolar (H+)-ATPase G subunit
- vacuolar ATP synthase, subunit G
- H+-transporting two-sector ATPase
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- H+-exporting ATPase
- ATPase
- transporter
Pathways
Biological processes and signaling networks where the Atp6v1g2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- Alzheimer disease
- inguinal hernia
- glioblastoma
- glioblastoma cancer
- osteoarthritis
- myositis
regulates
- H+
role in cell
- apoptosis
- growth
- acidification in
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- cellular membrane
- vesicles
- cytosol
- synaptic vesicles
- perikaryon
- axons
- dendrites
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v1g2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macroautophagy
Cellular Component
Where in the cell the gene product is active
- vacuolar proton-transporting V-type ATPase, V1 domain
- melanosome
- cytosol
- synaptic vesicle membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein binding
- proton-transporting ATPase activity, rotational mechanism