Atp6v1e1 Gene Summary [Mouse]
Enables proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Acts upstream of or within proton transmembrane transport. Located in several cellular components, including apical plasma membrane; endosome; and microvillus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Orthologous to human ATP6V1E1 (ATPase H+ transporting V1 subunit E1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Atp6v1e1 |
| Official Name | ATPase, H+ transporting, lysosomal V1 subunit E1 [Source:MGI Symbol;Acc:MGI:894326] |
| Ensembl ID | ENSMUSG00000019210 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V1 subunit E1 |
| Synonyms | 2410029D23Rik, ARCL2C, ATP6E, ATP6E2, ATP6V1E, ATPase, H+ transporting, lysosomal V1 subunit E1, ATPase H+ transporting V1 subunit E1, D6Ertd385e, P31, Vacuolar H+ATPase 31kDa, V-ATPase E, V-ATPase E2, V-ATPase V1-E1, Vma4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v1e1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- ATP synthase (E/31 kDa) subunit
- H+-exporting ATPase
- transporter
Pathways
Biological processes and signaling networks where the Atp6v1e1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- squamous cell cancer
- glioblastoma
- glioblastoma cancer
- liver cancer
- Alzheimer disease
- oligodendroglioma
- glioma formation
- hepatocellular carcinoma
- dilated cardiomyopathy
regulates
- ATP6V1E1
- H+
- TF
- GDP
- Jnk1
- vacuolar H+ ATPase
role in cell
- Clathrin mediated endocytosis by
- acidification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- intracellular compartment
- intracellular space
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- cytosol
- apical membrane
- endocytic zone
- synaptic vesicles
- early endosomes
- late endosomes
- brush border
- microvilli
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v1e1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macroautophagy
Cellular Component
Where in the cell the gene product is active
- proton-transporting two-sector ATPase complex
- vacuolar proton-transporting V-type ATPase, V1 domain
- extracellular vesicular exosome
- endosome
- microvillus
- cytosol
- synaptic vesicle membrane
- apical plasma membrane
- lysosomal membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-transporting ATPase activity, rotational mechanism
- ATPase binding