Me2 Gene Summary [Mouse]
Enables malate dehydrogenase (decarboxylating) (NAD+) activity. Predicted to be involved in malate metabolic process and regulation of NADP metabolic process. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including central nervous system; integumental system; metanephros; sensory organ; and skeleton. Orthologous to human ME2 (malic enzyme 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Me2 |
| Official Name | malic enzyme 2, NAD(+)-dependent, mitochondrial [Source:MGI Symbol;Acc:MGI:2147351] |
| Ensembl ID | ENSMUSG00000024556 |
| Bio databases IDs | |
| Aliases | malic enzyme 2, NAD(+)-dependent, mitochondrial |
| Synonyms | AK171786, D030040L20Rik, LOC100505264, malic enzyme 2, malic enzyme 2, NAD(+)-dependent, mitochondrial, NAD-ME, ODS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Me2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- electron carrier
- Malic enzyme, N-terminal domain
- malate dehydrogenase (decarboxylating)
- malic enzyme
- malate dehydrogenase (oxaloacetate-decarboxylating)
- enzyme
- malate dehydrogenase (oxaloacetate-decarboxylating) (NADP)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic generalized epilepsy
regulates
- NADPH
- TP53
- NADH
- adenosine triphosphate
- fumaric acid
- pyruvic acid
- glutamine
- malic acid
- GABA
role in cell
- production in
- activation in
- senescence
- lipogenesis in
- josamycin sensitivity
- metabolism in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Me2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- malate metabolic process
- pyruvate metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- intracellular membrane-bounded organelle
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- oxaloacetate decarboxylase activity
- metal ion binding
- NAD binding
- malic enzyme activity
- electron carrier activity
- malate dehydrogenase (decarboxylating) activity
- malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity