Tle4 Gene Summary [Mouse]
Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within Wnt signaling pathway and cellular response to leukemia inhibitory factor. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesenchyme; genitourinary system; and peripheral nervous system ganglion. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tle4 |
| Official Name | transducin-like enhancer of split 4 [Source:MGI Symbol;Acc:MGI:104633] |
| Ensembl ID | ENSMUSG00000024642 |
| Bio databases IDs | |
| Aliases | transducin-like enhancer of split 4 |
| Synonyms | 5730411M05Rik, BCE-1, ESG, ESG4, Esp2, E(spI), E(spl), ESTM13, ESTM14, GRG4, KIAA1261, TLE family member 4, transcriptional corepressor, transducin-like enhancer of split 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tle4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SP repeat domain
- transcription regulator
- WD40 repeats
- transcription co-repressor
- Groucho/TLE N-terminal Q-rich domain
- WD domain, G-beta repeat
- transcription factor binding
- WD40
- chromatin binding
- protein binding
- glutamine-rich domain
Pathways
Biological processes and signaling networks where the Tle4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- cervical cancer
- bipolar disorder
- non-insulin-dependent diabetes mellitus
- schizophrenia
- acute myeloid leukemia
- hypoplasia
- primary myelofibrosis
- male pattern hair loss
- metabolic syndrome X
phenotypes
- abnormal eye morphology
- decreased grip strength
- decreased heart weight
- increased circulating cholesterol level
- male infertility
- abnormal circulating calcium level
- abnormal circulating cholesterol level
- abnormal circulating serum albumin level
- abnormal circulating total protein level
- abnormal hematopoietic stem cell physiology
- abnormal long bone epiphyseal plate morphology
- abnormal long bone epiphyseal plate proliferative zone
- abnormal long bone hypertrophic chondrocyte zone
- abnormal lymphopoiesis
- abnormal spleen B cell follicle morphology
- abnormal thymus morphology
- decreased B cell number
- decreased DN2 thymocyte number
- decreased body weight
- decreased bone marrow cell number
- decreased bone mineral content
- decreased common myeloid progenitor cell number
- decreased compact bone thickness
- decreased double-positive T cell number
- decreased follicular B cell number
- decreased hematopoietic stem cell number
- decreased leukocyte cell number
- decreased long bone epiphyseal plate size
- decreased lymphocyte cell number
- decreased pre-pro B cell number
- decreased trabecular bone mass
- increased NK T cell number
- increased thymocyte apoptosis
- postnatal growth retardation
- premature death
- spleen hypoplasia
- thymus atrophy
- thymus hypoplasia
role in cell
- apoptosis
- proliferation
- number
- repression in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tle4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- chromatin binding