Srpk2 Gene Summary [Mouse]
Enables several functions, including 14-3-3 protein binding activity; ATP binding activity; and magnesium ion binding activity. Involved in several processes, including nuclear speck organization; positive regulation of neuron apoptotic process; and spliceosomal complex assembly. Located in cytoplasm and nucleus. Is expressed in central nervous system; neural retina; and olfactory epithelium. Orthologous to human SRPK2 (SRSF protein kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srpk2 |
| Official Name | serine/arginine-rich protein specific kinase 2 [Source:MGI Symbol;Acc:MGI:1201408] |
| Ensembl ID | ENSMUSG00000062604 |
| Bio databases IDs | |
| Aliases | serine/arginine-rich protein specific kinase 2 |
| Synonyms | mSRPK2, serine/arginine-rich protein specific kinase 2, SFRSK2, Srpk2 predicted, SRSF protein kinase 2, WBP6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srpk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- ATP binding
- protein binding
- magnesium ion binding
Pathways
Biological processes and signaling networks where the Srpk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- major depression
- bipolar disorder
- Alzheimer disease
- COVID-19
- non-insulin-dependent diabetes mellitus
- pervasive developmental disorder
- melanoma
- melanoma cancer
- Waldenström macroglobulinemia
role in cell
- expression in
- apoptosis
- phosphorylation in
- proliferation
- binding in
- accumulation in
- upregulation in
- cell cycle progression
- G1 phase
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- presynaptic regions
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srpk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- nuclear speck organization
- positive regulation of cell proliferation
- positive regulation of cell cycle
- protein phosphorylation
- spliceosomal complex assembly
- positive regulation of neuron apoptotic process
- regulation of mRNA processing
- angiogenesis
- innate immune response
- positive regulation of gene expression
- regulation of nuclear mRNA splicing, via spliceosome
- cell differentiation
- peptidyl-serine phosphorylation
- positive regulation of viral genome replication
- negative regulation of viral genome replication
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- RNA binding
- protein serine/threonine kinase activity
- 14-3-3 protein binding