Tmem132a Gene Summary [Mouse]
Enables protein homodimerization activity. Acts upstream of or within negative regulation of protein catabolic process; positive regulation of Wnt protein secretion; and positive regulation of Wnt signaling pathway. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb bud; lung; and spinal ganglion. Orthologous to human TMEM132A (transmembrane protein 132A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem132a |
| Official Name | transmembrane protein 132A [Source:MGI Symbol;Acc:MGI:2147810] |
| Ensembl ID | ENSMUSG00000024736 |
| Bio databases IDs | |
| Aliases | transmembrane protein 132A |
| Synonyms | 6720481D13Rik, GBP, HSPA5BP1, Orai1, transmembrane protein 132A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem132a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein family 132
- Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem132a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein catabolic process
- positive regulation of Wnt receptor signaling pathway
- positive regulation of Wnt protein secretion
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- Golgi membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity