Atl3 Gene Summary [Mouse]
Predicted to enable GTP binding activity; GTPase activity; and identical protein binding activity. Predicted to be involved in several processes, including Golgi organization; positive regulation of endoplasmic reticulum tubular network organization; and protein homooligomerization. Predicted to be located in endoplasmic reticulum tubular network membrane. Is expressed in olfactory cortex ventricular layer; orbito-sphenoid; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1F. Orthologous to human ATL3 (atlastin GTPase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atl3 |
| Official Name | atlastin GTPase 3 [Source:MGI Symbol;Acc:MGI:1924270] |
| Ensembl ID | ENSMUSG00000024759 |
| Bio databases IDs | |
| Aliases | atlastin GTPase 3 |
| Synonyms | 4633402C03Rik, 5730596K20RIK, atlastin GTPase 3, AW228836, Contig3845 RC, DKFZp564J0863, HSN1F, LOC283241, RGD1309871 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Guanylate-binding protein, N-terminal domain
- GTPase
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum tubules
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- Golgi organization
- protein homooligomerization
- endoplasmic reticulum organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum tubular network
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- GTPase activity