Vps51 Gene Summary [Mouse]
Involved in protein targeting and vesicle-mediated cholesterol transport. Predicted to be located in nucleolus; recycling endosome; and trans-Golgi network. Predicted to be part of EARP complex and GARP complex. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 13. Orthologous to human VPS51 (VPS51 subunit of GARP complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps51 |
| Official Name | VPS51 GARP complex subunit [Source:MGI Symbol;Acc:MGI:1915755] |
| Ensembl ID | ENSMUSG00000024797 |
| Bio databases IDs | |
| Aliases | VPS51 GARP complex subunit |
| Synonyms | 1110014N23Rik, 3110057M17Rik, AI837850, ANG2, ANG3, C11orf2, C11ORF3, FFR, PCH13, RGD1560544, VPS51 GARP complex subunit, VPS51 subunit of GARP complex |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps51 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- COG (conserved oligomeric Golgi) complex component, COG2
- protein binding
- Vps51/Vps67
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- diabetic macular edema
- exudative age-related macular degeneration
- retinal vein occlusion
- pontocerebellar hypoplasia type 13
- pathologic myopia
- diabetic retinopathy
- polypoidal choroidal vasculopathy
- macular edema
regulated by
- 144DG11
role in cell
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Golgi Apparatus
- trans Golgi network
- nucleoli
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps51 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- lysosomal transport
- Golgi organization
- autophagy
- protein transport
- brain morphogenesis
- retrograde transport, endosome to Golgi
- vesicle-mediated cholesterol transport
- endocytic recycling
- Golgi vesicle transport
Cellular Component
Where in the cell the gene product is active
- GARP complex
- intracellular membrane-bounded organelle
- membrane
- cytosol
- Golgi apparatus
- recycling endosome
- nucleolus
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding