Gldc Gene Summary [Mouse]
Predicted to enable several functions, including glycine binding activity; glycine dehydrogenase (decarboxylating) activity; and vitamin B6 binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in mitochondrion. Is expressed in several structures, including central nervous system; integumental system; limb; sensory organ; and urinary system. Used to study glycine encephalopathy. Human ortholog(s) of this gene implicated in glycine encephalopathy and glycine encephalopathy 1. Orthologous to human GLDC (glycine decarboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gldc |
| Official Name | glycine decarboxylase [Source:MGI Symbol;Acc:MGI:1341155] |
| Ensembl ID | ENSMUSG00000024827 |
| Bio databases IDs | |
| Aliases | glycine decarboxylase |
| Synonyms | b2b2679Clo, D030049L12Rik, D19Wsu57e, GCE, GCE1, GCSP, glycine decarboxylase, HYGN1, LOC100911814 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gldc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- electron carrier
- vitamin binding
- pyridoxal phosphate binding
- binding protein
- glycine binding
- glycine dehydrogenase (decarboxylating)
- enzyme binding
- protein homodimerization
- AAT_I
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- non-ketotic hyperglycinemia
- metastasis
- glycine encephalopathy type 1
- hereditary disorder
- HER2 negative hormone receptor negative breast cancer
- Sylvius aqueduct stenosis
- organismal death
- diabetes mellitus
- overall survival
role in cell
- production in
- expression in
- cell viability
- migration
- growth
- proliferation
- accumulation
- invasion by
- accumulation in
- metabolism in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gldc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycine decarboxylation via glycine cleavage system
- glycine catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- glycine cleavage complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein homodimerization activity
- electron carrier activity
- lyase activity
- glycine binding
- glycine dehydrogenase (decarboxylating) activity
- pyridoxal binding