Tnrc6a Gene Summary [Mouse]
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein is highly similar to a human protein that functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The human protein associates with messenger RNAs and argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies, and inhibiting its expression delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | Tnrc6a |
| Official Name | trinucleotide repeat containing 6a [Source:MGI Symbol;Acc:MGI:2385292] |
| Ensembl ID | ENSMUSG00000052707 |
| Bio databases IDs | |
| Aliases | trinucleotide repeat containing 6a |
| Synonyms | 2010321I05RIK, 3110054G10RIK, CAGH26, D130023A07RIK, FAME6, GW1, GW182, MGC11932, TNRC6, trinucleotide repeat containing 6a, trinucleotide repeat containing adaptor 6A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnrc6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- silencing domain
- RNA recognition motif (RRM) superfamily
- M domain of GW182
- polyglutamine repeat
- TNRC6-PABC binding domain
- protein binding
- glutamine-rich domain
- Argonaute hook
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic intraepithelial neoplasia
- tumorigenesis
- chronic obstructive pulmonary disease
- non-insulin-dependent diabetes mellitus
- pervasive developmental disorder
- acute myeloid leukemia
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- prostatic intraepithelial neoplasm
role in cell
- phosphorylation in
- expression in
- quantity
- loss
- response
- assembly
- focus formation
- sunitinib resistance
- homologous recombination repair in
- focus formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- intracellular membrane-bounded organelle
- cytoplasmic mRNA processing body
- Cytoplasm
- perinuclear region
- endosomes
- Golgi Apparatus
- cytoplasmic particles
- cytoplasmic aggregates
- cytosol
- sister chromatids
- nucleoplasm
- multivesicular bodies
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnrc6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translation involved in gene silencing by miRNA
- gene silencing by miRNA
- endoderm development
- cytoplasmic mRNA processing body assembly
- cellular response to starvation
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- cytoplasmic mRNA processing body
- Golgi apparatus
- RNA-induced silencing complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- protein binding, bridging