Fam89b Gene Summary [Mouse]
Enables transcription corepressor binding activity. Involved in establishment of cell polarity; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of cell migration. Located in cytoplasm and lamellipodium. Is expressed in several structures, including branchial arch; heart valve; liver; nervous system; and sensory organ. Orthologous to human FAM89B (family with sequence similarity 89 member B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam89b |
| Official Name | family with sequence similarity 89, member B [Source:MGI Symbol;Acc:MGI:106595] |
| Ensembl ID | ENSMUSG00000024939 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 89, member B |
| Synonyms | 1110021A21Rik, family with sequence similarity 89 member B, family with sequence similarity 89, member B, LRAP25, MMTV, MTVR, MTVR1, Mtvr2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fam89b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine rich domain
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- F Actin
- cofilin
- LIMK1
role in cell
- activation
- activation in
- phosphorylation in
- migration
- polarization
- motility
- deregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fam89b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of SMAD protein import into nucleus
- establishment of cell polarity
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding