Hook2 Gene Summary [Mouse]
Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and microtubule binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to be located in cytosol and trans-Golgi network. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nose; respiratory system; and skin. Orthologous to human HOOK2 (hook microtubule tethering protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hook2 |
| Official Name | hook microtubule tethering protein 2 [Source:MGI Symbol;Acc:MGI:2181664] |
| Ensembl ID | ENSMUSG00000052566 |
| Bio databases IDs | |
| Aliases | hook microtubule tethering protein 2 |
| Synonyms | A630054I03Rik, h-hook2, HK2, hook microtubule-tethering protein 2, mHK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hook2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- Hook domain-containing proteins superfamily
- HOOK domain
- protein binding
- Intermediate filament protein
- Calcium binding and coiled-coil domain (CALCOCO1) like
- identical protein binding
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mother centriole
- intracellular membrane-bounded organelle
- basal bodies
- centrosome
- Golgi Apparatus
- microtubules
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hook2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- cytoskeleton-dependent intracellular transport
- endosome organization
- early endosome to late endosome transport
- protein transport
- endosome to lysosome transport
- cytoplasmic microtubule organization
- endocytosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- trans-Golgi network
- cytoplasm
- FHF complex
- intracellular membrane-bounded organelle
- cytosol
- HOPS complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- dynein light intermediate chain binding
- microtubule binding