Fermt3 Gene Summary [Mouse]
Enables integrin binding activity. Involved in several processes, including integrin activation; platelet aggregation; and regulation of cell-cell adhesion mediated by integrin. Located in podosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and skin. Used to study leukocyte adhesion deficiency 3. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (FERM domain containing kindlin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fermt3 |
| Official Name | fermitin family member 3 [Source:MGI Symbol;Acc:MGI:2147790] |
| Ensembl ID | ENSMUSG00000024965 |
| Bio databases IDs | |
| Aliases | fermitin family member 3 |
| Synonyms | FERM domain containing kindlin 3, fermitin family member 3, KIND3, KINDLIN-3, MIG-2, MIG2B, RGD1310168, UNC112C, URP2, URP2SF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fermt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FERM subdomain f3
- pleckstrin Homology binding region
- lipid binding
- Ubl1_cv_Nsp3_N-like
- integrin binding
- PH domain
- enzyme
- protein binding
- Pleckstrin homology-like domain
- Kindlin-2 N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- leukocyte adhesion deficiency III
- attention deficit hyperactivity disorder
- androgenic alopecia
- bleeding disorder
- essential thrombocythemia
- leukocyte adhesion deficiency
- major depression
- organismal death
role in cell
- proliferation
- activation in
- production in
- quantity
- migration
- cell spreading
- cytotoxicity
- recruitment
- formation
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- podosomes
- alpha granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fermt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- integrin-mediated signaling pathway
- substrate adhesion-dependent cell spreading
- regulation of cell-cell adhesion mediated by integrin
- platelet aggregation
- leukocyte cell-cell adhesion
- integrin activation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular vesicular exosome
- membrane
- cell-substrate junction
- extracellular region
- cell projection
- podosome
Molecular Function
What the gene product does at the molecular level
- integrin binding
- lipid binding