Xpnpep1 Gene Summary [Mouse]
Predicted to enable manganese ion binding activity; metalloaminopeptidase activity; and protein homodimerization activity. Predicted to be involved in bradykinin catabolic process; negative regulation of programmed cell death; and proteolysis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Xpnpep1 |
| Official Name | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble [Source:MGI Symbol;Acc:MGI:2180003] |
| Ensembl ID | ENSMUSG00000025027 |
| Bio databases IDs | |
| Aliases | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble |
| Synonyms | APP1, D230045I08Rik, SAMP, XPNPEP, XPNPEPL, XPNPEPL1, X-prolyl aminopeptidase 1, X-prolyl aminopeptidase (aminopeptidase P) 1, soluble |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xpnpep1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metallopeptidase family M24
- C-terminal region of peptidase_M24
- metalloexopeptidase
- peptidase
- aminopeptidase
- protein homodimerization
- protein binding
- Creatinase/Prolidase N-terminal domain
- APP_MetAP
- manganese ion binding
- X-Pro aminopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Xpnpep1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bradykinin catabolic process
- proteolysis
- negative regulation of programmed cell death
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- metalloaminopeptidase activity
- aminopeptidase activity
- manganese ion binding