XPNPEP1 Gene Summary [Human]
This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
Details
| Type | Retained Intron |
| Official Symbol | XPNPEP1 |
| Official Name | X-prolyl aminopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:12822] |
| Ensembl ID | ENSG00000108039 |
| Bio databases IDs | |
| Aliases | X-prolyl aminopeptidase 1, Xaa-Pro aminopeptidase 1 |
| Synonyms | APP1, D230045I08Rik, SAMP, XPNPEP, XPNPEPL, XPNPEPL1, X-prolyl aminopeptidase 1, X-prolyl aminopeptidase (aminopeptidase P) 1, soluble |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human XPNPEP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metallopeptidase family M24
- C-terminal region of peptidase_M24
- metalloexopeptidase
- peptidase
- aminopeptidase
- protein homodimerization
- protein binding
- Creatinase/Prolidase N-terminal domain
- APP_MetAP
- manganese ion binding
- X-Pro aminopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human XPNPEP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bradykinin catabolic process
- proteolysis
- negative regulation of programmed cell death
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- metalloaminopeptidase activity
- aminopeptidase activity
- manganese ion binding