Hspa12a Gene Summary [Mouse]
Predicted to enable ATP binding activity. Acts upstream of or within several processes, including import into nucleus; liver development; and macrophage activation. Predicted to be located in cytoplasm and nucleus. Is expressed in nervous system; retina; and white fat. Orthologous to human HSPA12A (heat shock protein family A (Hsp70) member 12A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspa12a |
| Official Name | heat shock protein 12A [Source:MGI Symbol;Acc:MGI:1920692] |
| Ensembl ID | ENSMUSG00000025092 |
| Bio databases IDs | |
| Aliases | heat shock protein 12A |
| Synonyms | 1700063D12Rik, AI118035, D5Mgi40, Gm19925, heat shock protein 12A, heat shock protein family A (Hsp70) member 12A, mKIAA0417 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hspa12a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Hspa12a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- heart failure
- obesity
- metabolic syndrome X
- colorectal cancer
- glaucoma
- open-angle glaucoma
- freckles
- weight gain
- ischemic injury
role in cell
- activation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hspa12a gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding