Podxl Gene Summary [Mouse]
Involved in several processes, including negative regulation of cell-cell adhesion; regulation of microvillus assembly; and regulation of synapse assembly. Acts upstream of or within leukocyte migration. Located in apical plasma membrane and microvillus membrane. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including genitourinary system; integumental system; intraembryonic coelom; nervous system; and sensory organ. Orthologous to human PODXL (podocalyxin like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Podxl |
| Official Name | podocalyxin-like [Source:MGI Symbol;Acc:MGI:1351317] |
| Ensembl ID | ENSMUSG00000025608 |
| Bio databases IDs | |
| Aliases | podocalyxin-like |
| Synonyms | gp135, Gp200, Ly102, PC, PCLP, PCLP-1, PDX, Podocalyxin, PODOCALYXIN-LIKE, PODXL1, RCC Antigen, TRA-1-60 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Podxl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- CD34/Podocalyxin family
- cytoplasmic domain
- protein binding
- cytosolic tail domain
- membrane-proximal domain
Pathways
Biological processes and signaling networks where the Podxl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- liver cancer
- epithelial cancer
- early onset hypertension
- herniation
- hydrops fetalis
- hepatocellular carcinoma
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- autosomal recessive juvenile Parkinson disease type 2
role in cell
- expression in
- adhesion
- formation
- migration
- lack
- development
- differentiation
- cell spreading
- invasiveness
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- ruffle
- Cytoplasm
- cell surface
- cell periphery
- intracellular membranes
- cellular membrane
- centrosome
- Endoplasmic Reticulum
- intercellular junctions
- lateral cell surfaces
- apical cell surfaces
- apical membrane
- presynaptic membrane
- nucleoli
- alpha granules
- pedicels
- podocyte filtration slit
- cellular protrusions
- microvilli
- filopodia
- cell membrane leading edge
- perikaryon
- exosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Podxl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial tube formation
- glomerular visceral epithelial cell development
- negative regulation of cell-cell adhesion
- negative regulation of cell adhesion
- cell adhesion
- cell migration
- positive regulation of cell-cell adhesion mediated by integrin
- positive regulation of cell migration
- regulation of microvillus assembly
Cellular Component
Where in the cell the gene product is active
- slit diaphragm
- centriolar satellite
- nucleolus
- plasma membrane
- microvillus membrane
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane raft
- ruffle
- filopodium
- apical plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding