Ctdspl Gene Summary [Mouse]
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and negative regulation of protein phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human CTDSPL (CTD small phosphatase like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ctdspl |
| Official Name | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like [Source:MGI Symbol;Acc:MGI:1916524] |
| Ensembl ID | ENSMUSG00000047409 |
| Bio databases IDs | |
| Aliases | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like |
| Synonyms | 2810418J22RIK, C3orf8, CTD small phosphatase like, CTDSP-like, HYA22, NIFL, NIF-like, PSR1, RBSP3, SCP3, YA22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctdspl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FCP1-like phosphatase, phosphatase domain
- protein binding
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- schizophrenia
- neoplasia
- epithelial cancer
- side effect
- breast carcinoma
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- breast cancer
- renal cell carcinoma
role in cell
- expression in
- growth
- survival
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctdspl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein phosphorylation
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- CTD phosphatase activity
- myosin phosphatase activity