Hdgfl3 Gene Summary [Mouse]
Enables microtubule binding activity. Involved in microtubule polymerization; negative regulation of microtubule depolymerization; and neuron projection development. Located in cytosol and nucleus. Is expressed in mesonephros; metanephros; and nervous system. Orthologous to human HDGFL3 (HDGF like 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdgfl3 |
| Official Name | HDGF like 3 [Source:MGI Symbol;Acc:MGI:1352760] |
| Ensembl ID | ENSMUSG00000025104 |
| Bio databases IDs | |
| Aliases | HDGF like 3 |
| Synonyms | 2700022B06RIK, CGI-142, HDGF-2, HDGF like 3, HDGFRP3, HRP-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hdgfl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- tubulin binding
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- hath domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- sleep apnea syndrome
regulates
- tubulin
role in cell
- morphogenesis
- outgrowth
- stabilization
- polymerization
- outgrowth in
- stabilization in
- bundling
- depolymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- neurites
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hdgfl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- signal transduction
- neuron projection development
- negative regulation of microtubule depolymerization
- microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- growth factor activity
- microtubule binding