Stxbp5l Gene Summary [Mouse]
Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within glucose homeostasis; negative regulation of insulin secretion; and regulation of exocytosis. Is active in neuromuscular junction and neuronal dense core vesicle. Is expressed in several structures, including alimentary system; brain; male reproductive gland or organ; spinal cord; and trigeminal nerve. Orthologous to human STXBP5L (syntaxin binding protein 5L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stxbp5l |
| Official Name | syntaxin binding protein 5-like [Source:MGI Symbol;Acc:MGI:2443815] |
| Ensembl ID | ENSMUSG00000022829 |
| Bio databases IDs | |
| Aliases | syntaxin binding protein 5-like |
| Synonyms | 9430094L02, A830015P08Rik, LLGL4, syntaxin binding protein 5L, syntaxin binding protein 5-like, T2dm1, t2md1, tomosyn-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stxbp5l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- SNARE motif
- LLGL2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- peripheral arterial disease
- small cell lung cancer
- androgenic alopecia
- neurodegeneration
- bacterial meningitis
regulates
- insulin
- D-glucose
- acetylcholine
role in cell
- exocytosis
- exocytosis by
- paired-pulse facilitation
- action potential
- synaptic strength
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- neuromuscular junctions
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stxbp5l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- Golgi to plasma membrane transport
- exocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- SNARE complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- GTPase activator activity
- myosin II binding