Zdhhc16 Gene Summary [Mouse]
Enables palmitoyltransferase activity. Involved in several processes, including DNA damage response; eye development; and protein palmitoylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including early conceptus; eye; genitourinary system; heart; and trunk somite. Orthologous to human ZDHHC16 (zinc finger DHHC-type palmitoyltransferase 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zdhhc16 |
| Official Name | zinc finger, DHHC domain containing 16 [Source:MGI Symbol;Acc:MGI:1921418] |
| Ensembl ID | ENSMUSG00000025157 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 16 |
| Synonyms | 1500015N03Rik, APH2, DHHC-16, zinc finger, DHHC domain containing 16, zinc finger DHHC-type palmitoyltransferase 16 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- DHHC palmitoyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- cardiomyopathy
- lung adenocarcinoma formation
- mental retardation
- bradycardia
role in cell
- morphology
- abnormal morphology
- DNA damage response
- palmitoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- eye development
- telencephalon development
- apoptotic process
- protein palmitoylation
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- protein binding
- palmitoyltransferase activity