Pln Gene Summary [Mouse]
Enables ATPase inhibitor activity and protein homodimerization activity. Involved in several processes, including locomotor rhythm; negative regulation of calcium ion import into sarcoplasmic reticulum; and visual learning. Acts upstream of or within several processes, including muscle cell cellular homeostasis; regulation of calcium ion transport; and regulation of heart contraction. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; ear; heart; nervous system; and skeleton. Used to study centronuclear myopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pln |
| Official Name | phospholamban [Source:MGI Symbol;Acc:MGI:97622] |
| Ensembl ID | ENSMUSG00000038583 |
| Bio databases IDs | |
| Aliases | phospholamban |
| Synonyms | CMD1P, CMH18, Phospholamban, PLB, Plm |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- camkii phosphorylation site
- phospholamban, sarcolipin, and sarcolamban family of bioactive peptides
- enzyme inhibitor activity
- protein binding
- identical protein binding
- ATPase binding
- Phospholamban
- cytoplasmic domain
- ATPase inhibitor activity
- transmembrane domain
- protein homodimerization
- ion channel binding
- Pka phosphorylation site
- transporter
Pathways
Biological processes and signaling networks where the Pln gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congestive heart failure
- dilated cardiomyopathy
- heart failure
- cardiac fibrosis
- fibrosis
- atrial fibrillation
- colorectal adenoma
- colorectal adenoma formation
- familial hypertrophic cardiomyopathy type 18
- ulcerative colitis
role in cell
- activation in
- size
- elongation
- relaxation
- contraction
- shortening
- function
- homeostasis
- abnormal morphology
- twitch
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- caveolae fraction
- membrane fraction
- perinuclear region
- cellular membrane
- sarcoplasmic reticulum
- vesicles
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
- sarcoplasmic reticulum vesicle
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell membrane potential
- muscle cell homeostasis
- negative regulation of ATPase activity
- regulation of cardiac muscle cell contraction
- cytosolic calcium ion homeostasis
- regulation of heart contraction
- blood circulation
- negative regulation of calcium ion import
- cardiac muscle tissue development
- cellular calcium ion homeostasis
- regulation of the force of heart contraction
- acrosome assembly
- Notch signaling pathway
- negative regulation of catalytic activity
- negative regulation of calcium ion transport
- negative regulation of heart rate
- regulation of calcium ion transport
- regulation of the force of heart contraction by cardiac conduction
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- relaxation of cardiac muscle
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- mitochondrial membrane
- sarcoplasmic reticulum
- mitochondrion
- membrane
- endoplasmic reticulum
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- enzyme inhibitor activity
- ATPase inhibitor activity
- ATPase binding