Dgke Gene Summary [Mouse]
Predicted to enable ATP-dependent diacylglycerol kinase activity. Involved in modulation of chemical synaptic transmission and phosphatidylinositol biosynthetic process. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgke |
| Official Name | diacylglycerol kinase, epsilon [Source:MGI Symbol;Acc:MGI:1889276] |
| Ensembl ID | ENSMUSG00000000276 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase, epsilon |
| Synonyms | AHUS7, DAGK5, DAGK6, DGK, Dgk epsilon, DGK ε, diacylglycerol kinase epsilon, diacylglycerol kinase, epsilon, diacylglycerol kinase ε, diacylglycerol kinase, ε, NPHS7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dgke often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- lipid kinase, YegS/Rv2252/BmrU family
- diacylglycerol kinase
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Diacylglycerol kinase catalytic domain
- Diacylglycerol kinase catalytic domain (presumed)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nephrotic syndrome type 7
- severe COVID-19
- tonic seizure
- susceptibility to atypical hemolytic uremic syndrome type 7
- atypical hemolytic uremic syndrome
- nephrosis
- factor H-associated hemolytic uremic syndrome
- tonic-clonic seizure
- acute myeloid leukemia
- hemolytic uremic syndrome
role in cell
- expression in
- activation in
- adhesion
- activation
- apoptosis
- migration
- angiogenesis by
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cellular membrane
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dgke gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic transmission
- phosphatidylinositol biosynthetic process
- protein kinase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- lipid phosphorylation
- diacylglycerol metabolic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- diacylglycerol kinase activity
- kinase activity