Lztfl1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within flagellated sperm motility and spermatogenesis. Located in cilium; cytoplasm; and manchette. Is expressed in several structures, including brain; sensory organ; testis; and upper jaw incisor. Used to study Bardet-Biedl syndrome 17. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 17. Orthologous to human LZTFL1 (leucine zipper transcription factor like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lztfl1 |
| Official Name | leucine zipper transcription factor-like 1 [Source:MGI Symbol;Acc:MGI:1934860] |
| Ensembl ID | ENSMUSG00000025245 |
| Bio databases IDs | |
| Aliases | leucine zipper transcription factor-like 1 |
| Synonyms | 5530402H04Rik, 6130400H19RIK, BBS17, leucine zipper transcription factor-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lztfl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Leucine zipper
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Bardet-Biedl syndrome type 17
- COVID-19
- nonalcoholic fatty liver disease
- obesity
- covid-19 death
- multiple sclerosis
- mouth mucosal ulcer
- tinnitus
- atresia
- hyperplasia
role in cell
- expression in
- degeneration
- signaling in
- size
- morphology
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- manchette
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lztfl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- spermatogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cilium
- cytosol
- manchette
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding