Ptprj Gene Summary [Mouse]
Enables protein tyrosine phosphatase activity. Involved in several processes, including peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; regulation of cell migration; and regulation of signal transduction. Acts upstream of or within heart development; oligodendrocyte differentiation; and vasculogenesis. Located in immunological synapse and ruffle membrane. Is expressed in midbrain; renal calyx; renal pelvis; and superior colliculus. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung squamous cell carcinoma; and thrombocytopenia. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ptprj |
| Official Name | protein tyrosine phosphatase, receptor type, J [Source:MGI Symbol;Acc:MGI:104574] |
| Ensembl ID | ENSMUSG00000025314 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, J |
| Synonyms | BET, Byp, CD148, DEP-1, HPTP eta, protein tyrosine phosphatase receptor type J, protein tyrosine phosphatase, receptor type, J, Ptpb2, PTPbeta2, PTP-ETA, PTP ETA C, PTP-ETA M, R-PTP-ETA, R-PTP-J, SCC1, THC10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptprj often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- beta-catenin binding
- catalytic domain
- ectodomain
- platelet-derived growth factor receptor binding
- Protein tyrosine phosphatase, catalytic domain
- Fibronectin type 3 domain
- PTP_DSP_cys
- protein binding
- phosphatase domain
- Protein tyrosine phosphatase, catalytic domain motif
- PTPase domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- TM proximal of protein tyrosine phosphatase, receptor type J
- Protein-tyrosine phosphatase
- cytoplasmic domain
- gamma-catenin binding
- FN3
- transmembrane domain
- phosphatase
- intracellular domain
- cadherin binding
Pathways
Biological processes and signaling networks where the Ptprj gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- major depression
- colorectal carcinomagenesis
- hypertension
- colon cancer
- thrombocytopenia type 10
role in cell
- expression in
- proliferation
- quantity
- number
- growth
- inactivation in
- phosphorylation in
- formation
- activation in
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cell surface
- cellular membrane
- intercellular junctions
- immunological synapses
- cell-cell contacts
- specific granule membrane
- membrane ruffles
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptprj gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- contact inhibition
- negative regulation of MAP kinase activity
- positive chemotaxis
- negative regulation of cell proliferation
- vasculogenesis
- positive regulation of cell adhesion
- blood coagulation
- negative regulation of epidermal growth factor receptor signaling pathway
- positive regulation of Fc receptor mediated stimulatory signaling pathway
- positive regulation of calcium-mediated signaling
- heart development
- angiogenesis
- negative regulation of cell growth
- cytokine-mediated signaling pathway
- positive regulation of macrophage chemotaxis
- platelet formation
- positive regulation of tumor necrosis factor production
- peptidyl-tyrosine dephosphorylation
- positive regulation of peptidyl-tyrosine phosphorylation
- T cell receptor signaling pathway
- oligodendrocyte differentiation
- positive regulation of platelet activation
- B cell differentiation
- protein dephosphorylation
- platelet-derived growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- negative regulation of vascular permeability
- negative regulation of insulin receptor signaling pathway
- negative regulation of T cell receptor signaling pathway
- positive regulation of focal adhesion assembly
- glucose homeostasis
- regulation of cell adhesion
- positive regulation of phagocytosis
- negative regulation of platelet-derived growth factor receptor signaling pathway
- positive regulation of protein kinase B signaling cascade
- negative regulation of cell migration
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- extracellular vesicular exosome
- ruffle membrane
- plasma membrane
- specific granule membrane
- immunological synapse
- cell surface
Molecular Function
What the gene product does at the molecular level
- gamma-catenin binding
- protein kinase binding
- delta-catenin binding
- protein binding
- platelet-derived growth factor receptor binding
- protein tyrosine phosphatase activity
- cadherin binding
- phosphatase activity
- beta-catenin binding
- mitogen-activated protein kinase binding