Acot9 Gene Summary [Mouse]
Enables acetyl-CoA hydrolase activity and long-chain fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and short-chain fatty acid metabolic process. Located in mitochondrial matrix. Is expressed in cortical plate; dorsal root ganglion; trigeminal ganglion; and vagus ganglion. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Acot9 |
| Official Name | acyl-CoA thioesterase 9 [Source:MGI Symbol;Acc:MGI:1928939] |
| Ensembl ID | ENSMUSG00000025287 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 9 |
| Synonyms | 0610041P13Rik, ACATE2, acyl-CoA thioesterase 9, CGI-16, MT-ACT48, MTE-2, p48, U8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acot9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyl-CoA hydrolase
- acetyl-CoA hydrolase
- hot_dog
- enzyme
- protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cardiomyopathy
- breast carcinoma
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- septic shock
- glioblastoma
- glioblastoma cancer
- melanoma
regulates
- acyl-coenzyme A
- long chain fatty acid
- short chain fatty acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acot9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- acetyl-CoA hydrolase activity
- long-chain acyl-CoA hydrolase activity
- acyl-CoA hydrolase activity
- carboxylic ester hydrolase activity