Brd7 Gene Summary [Mouse]
Enables transcription corepressor activity. Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle and regulation of gene expression. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and tooth. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brd7 |
| Official Name | bromodomain containing 7 [Source:MGI Symbol;Acc:MGI:1349766] |
| Ensembl ID | ENSMUSG00000031660 |
| Bio databases IDs | |
| Aliases | bromodomain containing 7 |
| Synonyms | BP75, bromodomain containing 7, CELTIX1, NAG4, Ptpn13ip, SMARCI1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brd7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- transcription co-activator
- nucleic acid binding
- transcription co-repressor
- protein binding activity, bridging
- transcription factor binding
- p53 binding
- protein binding
- sequence-specific DNA binding
- Bromodomain
- double-stranded DNA binding
- Domain of unknown function (DUF3512)
Pathways
Biological processes and signaling networks where the Brd7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- neoplasia
- inflammatory bowel disease
- liver cancer
- breast cancer
- hepatocellular carcinoma
- neoplastic cell transformation
- globozoospermia
- rectum cancer
role in cell
- phosphorylation in
- expression in
- apoptosis
- translation in
- transcription in
- cell viability
- AZD7762 sensitivity
- abnormal morphology
- JQ1 resistance
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brd7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- positive regulation of gene expression, epigenetic
- positive regulation of cell differentiation
- positive regulation of myoblast differentiation
- regulation of nucleotide-excision repair
- regulation of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of T cell differentiation
- Wnt receptor signaling pathway
- negative regulation of G1/S transition of mitotic cell cycle
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear matrix
- cytosol
- kinetochore
- RSC complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding
- transcription coactivator activity
- histone binding
- transcription corepressor activity
- histone acetyl-lysine binding
- transcription regulatory region sequence-specific DNA binding