Rabggtb Gene Summary [Mouse]
Predicted to enable isoprenoid binding activity; small GTPase binding activity; and zinc ion binding activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein geranylgeranylation. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Is expressed in several structures, including central nervous system; genitourinary system; liver; stomach; and thymus. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Rabggtb |
| Official Name | Rab geranylgeranyl transferase, b subunit [Source:MGI Symbol;Acc:MGI:99537] |
| Ensembl ID | ENSMUSG00000038975 |
| Bio databases IDs | |
| Aliases | Rab geranylgeranyl transferase, b subunit |
| Synonyms | Ggt2 β, GGTase II β, GGTB, Rab geranylgeranyl transferase, b subunit, Rab geranylgeranyltransferase subunit beta, Rab geranylgeranyltransferase subunit β, RABGGT beta, RABGGT β, β RabGGTase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rabggtb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prenyltransferase and squalene oxidase repeat
- ISOPREN_C2_like
- zinc ion binding
- enzyme binding
- enzyme
- protein binding
- isoprenoid binding
- RAB-protein geranylgeranyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- melanoma
- melanoma cancer
- systemic lupus erythematosus
- adenocarcinoma
- tumor
- large cell lung carcinoma
- large cell lung cancer
regulates
role in cell
- growth
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rabggtb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein geranylgeranylation
- visual perception
Cellular Component
Where in the cell the gene product is active
- Rab-protein geranylgeranyltransferase complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- small GTPase binding
- Rab geranylgeranyltransferase activity